I happened on this question in the DPR forum and as usual it went astray. As everyone here knows, there has been an ongoing discussion of noise at high ISO and which camera is better at high ISO's or how to get around the noise when you use high ISO. So I was wondering if the noise at high ISO is really a problem or is it just a forum issue that is raised for debat and comparison discussions? After deciding on speed and aperture and then focus on a subject, I think the ISO setting has the greatest impact on your final image. It seems to me that the D2x which seems to get more than it's fair share of critisizm for high ISO noise works great under 800 ISO and I very rarely shoot at an ISO higher than 400, usually not even that high. I have several fast lenses which I try to use outdoors if I am shooting early or late in the day or in shade or inside w/o flash but they are heavy to carry around. I have begun to take my travel tripod or monopod with me more often when I intend to shoot in these conditions (and have the time to set it up) and then adjust in PS if it needs to be lightened slightly. I have Noise Ninja which works pretty well usually but does give a bit of a painted or plastic look when used extensively. I find that ISO 200 is my most common setting and this works out pretty well. Do you trade off high ISO to avoid using a tripod or flash or carrying heavy fast lenses or do you adjust your ISO up and then try to fix it later in computer?