I used a unusual combination for this one (self-portrait). A wide angle Zoom + an ISO 800 setting and no strobe. I also converted to BW because I usually like the noise in BW pics. I found an interesting way to seriously reduce the noise as well in NC 4.3.1 My good friend Benoit G lead me to it. I use Moire Noise reduction and it clears the chroma noise quite efficiently. All the noise left looks like film grain rather than color noise.