Nicole - come on now. Don't you think this is a pretty broad question?
Ok - as a life long New Yorker, allow me to answer you the question that you posed. I suggest that you shoot Manhattan, the Bronx, Brooklyn, Staten Island and Queens. Does that help you at all?
I realize that this may be read as a smart *ss comment, but the point I am making is that asking a question like "what to shoot in NYC" is sort of pointless. I am certainly not disparaging you; just trying to get you (and others who post similar non-specific questions) to understand that it would take me about 2 days to type a list of "where to go to take good pictures" in NYC.
How about giving us the length of time you have available, what type of photography subjects are you interested in (people, architecture, scenics, animals, flowers, street scenes), whether you have access to transportation within the City, what kind of gear you have at your disposal, etc. Then folks can begin to narrow the field and give you advice that actually might help you.
Hope I am not coming across as too obnoxious (I am, afterall, a New Yorker!), but I would truly like to help you since I have a passion for showing off our great city to strangers.
If you are a 'street' photographer, East or West Village, Lower East Side. Little India (between First and Second Avenue at 5th st (I think)., Chinatown.
Anywhere on Houston St (pronounced How-stan in NYC)
Yeah. It was a pretty broad question! We are going to be there all day Saturday. We are taking the train into Grand Central and are planning walking, maybe a couple cab rides. I have a Nikon d40, 18-55 and 55-200 lens and sb600 flash. Besides the obvious popular places everyone knows about, I was wondering if there was anything an out of towner wouldn't know about. People, scenics, animals, flowers, street scenes.
Then pretty much anywhere else, financial district is interesting as well. You should really ask which area to avoid, I liked my walk from TimeSquare to the Empire State building as well as a little further south you have the Flatiron building which is within an interesting area Photography wise. But pretty much anywhere is interesting - it is NYC after all.
People usually don't shoot or talk too much about Canal Street which is a very interesting area on a Saturday!
I like South Street Sea Port at the end of the day, you get nice colors over the Brooklyn bridge, Brooklyn Heights for a nice Downtown view, the free ferry to staten island, lower east side, soho and of course central park
Grand Central Terminal >>>>Rockefeller Center>>>>>>Walk 5th ave going towards Central Park>>>>>Central Park>>>>>Museum Mile>>>>>Times Square/Broadway>>>>>Downtown Battery Park South Street Seaport>>>>>Grand Central.
You will have countless opportunities for some great images. Too much to see in one day. Hope you have a great visit, looking forward to seeing the pics